ePitope Informatics is a bioinformatics company formed in March 2000 to provide services for epitope
discovery and analysis. Particular foci are epitope prediction for the identification
and targeting of antibody epitopes, and epitope contextual analysis.
ePitope Informatics operates globally with clients working in areas
and biotherapeutic agent design, and antibody production and targeting for diagnostics and life
science research. To date, ePitope Informatics' clients have come from
biopharmaceutical companies, hospitals, medical schools, research institutes
ePitope Informatics is developing new services for epitope redesign for
modifying the immunogenicity of vaccine
and biotherapeutic agents.
In-house service provision utilises:
An up-to-date comprehensive library of
commercially licensed, proprietary and open-source scientific software
and databases, including Discovery Studio software from BIOVIA (formerly Accelrys).
High performance computing
NVIDIA professional graphics workstations and stereoscopic 3-D viewing
hardware (from NVIDIA and StereoGraphics/Real D) for
protein modelling and epitope contextual analysis .
resources for secure Internet-based operation and service delivery.
At ePitope Informatics, our goal is to
achieve the highest quality of
service and support possible for all users.
We also aim to keep our services:
cutting-edge of in silico protein analysis.
scientists' needs by constructively responding to
Accessible and easy to use.
The bigger picture
From genome to proteome
Genes encode proteins. The exponential increase in genetic
from the Human Genome Project and other genome
sequencing efforts, is
producing a vast wealth of protein sequence
information. As genome
sequencing projects are completed,
research emphasis will increasingly
redirect towards the proteome,
the protein complement of an organism.
Accordingly, this shift in
emphasis will heighten the importance of
proteomics, the study of
an organism's proteome, and especially in the areas
therapeutics (more than 95% of drug targets are proteins),
and molecular biology.
Proteomics target molecules
Thus, genome sequencing is just the beginning. The structure and
function of most of the proteins encoded by the tens of thousands
being sequenced, remain to be determined. Further
increases in the number of
different proteins for investigation occur
as a result of:
Post-translational modification of proteins in cells.
multiple functions (in the same and different
cells) that may be
regulated by post-translational
and individual variations in the same protein
activity) that occur as a result of innate
and acquired differences in
genome and/or coding sequences.
Antibodies and epitopes
Epitopes are regions on molecules that specifically bind antibodies
(see rotating protein molecule on Home page).
protein epitopes, antibodies are key tools for investigating:
structure, function and activity.
expression and location.
interaction with other macromolecules and small
Antibody applications include:
Immunoconjugate production (toxins, drugs, isotopes).
(e.g. of cancer, autoimmune and other
inflammatory diseases and allergic conditions).
New technologies utilising antibodies for
proteomics studies and
diagnostics, include :
profiling protein arrays (protein-antibody interactions on
high-throughput protein arrays).
High-throughput ELISA protein array systems.
microscopy arrays (detects antibody-protein
interactions at high
sensitivity without the need for tagging).
The exponential increase in the number of
target protein sequences
and structures becoming available combined with an increasing variety
of antibody applications, will generate the need for a
increased number of new antibodies.
The role of ePitope Informatics
Our goal is to promote and enhance
antibody-centred investigation through offering services for the
identification, analysis and targeting of antibody epitopes
at the surface of proteins.
Longer term aims for ePitope Informatics include:
new services for linear and conformational antibody
educational facility for undergraduate and
postgraduate students seeking
to pursue a period of time in
industry as part of an intercalated degree
In this situation, ePitope Informatics would aim to provide a
and stimulating, high quality teaching and
learning environment for the
pursuit of research project
work in the areas of pure and applied
Copyright © 2020 ePitope Informatics
Consensus epitope prediction
MGMT - peak
shown in gold).